Ecological approach of macrolide-lincosamides-streptogramin producing Actinomyces from Cuban soils

Binding of novel macrolide structures to macrolides-lincosamides-streptogramin B-resistant ribosomes inhibits protein synthesis and bacterial growth.

Dimethylation of adenine 2058 in 23S rRNA renders bacteria resistant to macrolides, lincosamides, and streptogramin B (MLS resistance), because the antibiotic binding site on the altered 50S ribosomal subunit is no longer accessible. We now report that certain 6-O-methyl-11,12-cyclic carbamate derivatives of erythromycin are able to bind to dimethylated MLS-resistant 50S ribosomal subunits, thu...

Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Macrolide-lincosamide-streptogramin resistance patterns in Clostridium perfringens from animals.

Different patterns of resistance against commonly used macrolide, lincosamide, and streptogramin antibiotics were found in Clostridium perfringens of animal origin. The patterns were designated as (i) macrolide-lincosamide-streptogramin group B generalized resistance, (ii) macrolide-lincosamide generalized resistance, (iii) macrolide-lincosamide inducible resistance, and (iv) macrolide-lincosam...

Inducible macrolides-lincosamides-streptogramin B resistance in Bacteroides species.

The first evidence is presented for the presence of inducible macrolides-lincosamides-streptogramin B resistance in Bacteroides species. Different macrolides induced clindamycin resistance in Bacteroides vulgatus RYC18F6, an erythromycin-resistant and clindamycin-susceptible strain. A study of 144 Bacteroides isolates indicated that erythromycin resistance was linked to diminished clindamycin s...

Introducing antimicrobial exopolymer-producing actinobacteria from soils of Iran

Exopolymers (EPS) are high-molecular-weight polymers secreted by some micro-organisms and have several applications in food, pharmaceutical, packaging and agricultural industries, as well as medicine. Actinobacteria are valuable bacteria in biotechnology and many commercial drugs such as antibiotics, antioxidants and immune-suppressant agents are derived from Actinobacteria. Recently, their oth...